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Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

Voltage-dependent Na(+) channels are crucial for electrical signalling in excitable cells. Membrane depolarization initiates asynchronous movements in four non-identical voltage-sensing domains of the Na(+) channel. It remains unclear to what extent this structural asymmetry influences pore gating a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Goldschen-Ohm, Marcel P., Capes, Deborah L., Oelstrom, Kevin M., Chanda, Baron
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562458/
https://ncbi.nlm.nih.gov/pubmed/23322038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2356
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