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Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel
Voltage-dependent Na(+) channels are crucial for electrical signalling in excitable cells. Membrane depolarization initiates asynchronous movements in four non-identical voltage-sensing domains of the Na(+) channel. It remains unclear to what extent this structural asymmetry influences pore gating a...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Pub. Group
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562458/ https://ncbi.nlm.nih.gov/pubmed/23322038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2356 |
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