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Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor
Voltage-dependent ion channels are crucial for generation and propagation of electrical activity in biological systems. The primary mechanism for voltage transduction in these proteins involves the movement of a voltage-sensing domain (D), which opens a gate located on the cytoplasmic side. A distin...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289344/ https://ncbi.nlm.nih.gov/pubmed/22308389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115575109 |
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