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Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor

Voltage-dependent ion channels are crucial for generation and propagation of electrical activity in biological systems. The primary mechanism for voltage transduction in these proteins involves the movement of a voltage-sensing domain (D), which opens a gate located on the cytoplasmic side. A distin...

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Main Authors: Capes, Deborah L., Arcisio-Miranda, Manoel, Jarecki, Brian W., French, Robert J., Chanda, Baron
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289344/
https://ncbi.nlm.nih.gov/pubmed/22308389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115575109
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