Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

Although red blood cell (RBC) transfusions can be lifesaving, they are not without risk. In critically ill patients, RBC transfusions are associated with increased morbidity and mortality, which may increase with prolonged RBC storage before transfusion. The mechanisms responsible remain unknown. We...

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Autori principali: Hod, Eldad A., Zhang, Ning, Sokol, Set A., Wojczyk, Boguslaw S., Francis, Richard O., Ansaldi, Daniel, Francis, Kevin P., Della-Latta, Phyllis, Whittier, Susan, Sheth, Sujit, Hendrickson, Jeanne E., Zimring, James C., Brittenham, Gary M., Spitalnik, Steven L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Transfusion Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879099/
https://ncbi.nlm.nih.gov/pubmed/20299509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-245001
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