Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron

Transfusions of RBCs stored for longer durations are associated with adverse effects in hospitalized patients. We prospectively studied 14 healthy human volunteers who donated standard leuko-reduced, double RBC units. One unit was autologously transfused “fresh” (3-7 days of storage), and the other...

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Autors principals: Hod, Eldad A., Brittenham, Gary M., Billote, Genia B., Francis, Richard O., Ginzburg, Yelena Z., Hendrickson, Jeanne E., Jhang, Jeffrey, Schwartz, Joseph, Sharma, Shruti, Sheth, Sujit, Sireci, Anthony N., Stephens, Hannah L., Stotler, Brie A., Wojczyk, Boguslaw S., Zimring, James C., Spitalnik, Steven L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Transfusion Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242722/
https://ncbi.nlm.nih.gov/pubmed/22021369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-371849
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