Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron

Transfusions of RBCs stored for longer durations are associated with adverse effects in hospitalized patients. We prospectively studied 14 healthy human volunteers who donated standard leuko-reduced, double RBC units. One unit was autologously transfused “fresh” (3-7 days of storage), and the other...

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Bibliographic Details
Main Authors: Hod, Eldad A., Brittenham, Gary M., Billote, Genia B., Francis, Richard O., Ginzburg, Yelena Z., Hendrickson, Jeanne E., Jhang, Jeffrey, Schwartz, Joseph, Sharma, Shruti, Sheth, Sujit, Sireci, Anthony N., Stephens, Hannah L., Stotler, Brie A., Wojczyk, Boguslaw S., Zimring, James C., Spitalnik, Steven L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Transfusion Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242722/
https://ncbi.nlm.nih.gov/pubmed/22021369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-371849
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