Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

The secreted ligand Sonic Hedgehog (Shh) organizes the pattern of cellular differentiation in the ventral neural tube. For the five neuronal subtypes, increasing levels and durations of Shh signaling direct progenitors to progressively more ventral identities. Here we demonstrate that this mode of a...

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Detalhes bibliográficos
Main Authors: Ribes, Vanessa, Balaskas, Nikolaos, Sasai, Noriaki, Cruz, Catarina, Dessaud, Eric, Cayuso, Jordi, Tozer, Samuel, Yang, Lin Lin, Novitch, Ben, Marti, Elisa, Briscoe, James
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878655/
https://ncbi.nlm.nih.gov/pubmed/20516201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.559910
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