Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages

Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiatio...

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Autors principals: Wong, Won F, Nakazato, Megumi, Watanabe, Toshio, Kohu, Kazuyoshi, Ogata, Takehiro, Yoshida, Naomi, Sotomaru, Yusuke, Ito, Mamoru, Araki, Kimi, Telfer, Janice, Fukumoto, Manabu, Suzuki, Daisuke, Sato, Takehito, Hozumi, Katsuto, Habu, Sonoko, Satake, Masanobu
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878468/
https://ncbi.nlm.nih.gov/pubmed/20102410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03230.x
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