Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages

Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiatio...

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Detalhes bibliográficos
Main Authors: Wong, Won F, Nakazato, Megumi, Watanabe, Toshio, Kohu, Kazuyoshi, Ogata, Takehiro, Yoshida, Naomi, Sotomaru, Yusuke, Ito, Mamoru, Araki, Kimi, Telfer, Janice, Fukumoto, Manabu, Suzuki, Daisuke, Sato, Takehito, Hozumi, Katsuto, Habu, Sonoko, Satake, Masanobu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878468/
https://ncbi.nlm.nih.gov/pubmed/20102410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03230.x
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