Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority of Dll4 over Dll1 with respect to induction o...

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Bibliographic Details
Published in:eLife
Main Authors: Hirano, Ken-ichi, Suganami, Akiko, Tamura, Yutaka, Yagita, Hideo, Habu, Sonoko, Kitagawa, Motoo, Sato, Takehito, Hozumi, Katsuto
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986876/
https://ncbi.nlm.nih.gov/pubmed/31934853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50979
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