Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority of Dll4 over Dll1 with respect to induction o...

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Publicado en:eLife
Autores principales: Hirano, Ken-ichi, Suganami, Akiko, Tamura, Yutaka, Yagita, Hideo, Habu, Sonoko, Kitagawa, Motoo, Sato, Takehito, Hozumi, Katsuto
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986876/
https://ncbi.nlm.nih.gov/pubmed/31934853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50979
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