Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority of Dll4 over Dll1 with respect to induction o...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Hirano, Ken-ichi, Suganami, Akiko, Tamura, Yutaka, Yagita, Hideo, Habu, Sonoko, Kitagawa, Motoo, Sato, Takehito, Hozumi, Katsuto
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2020
Sujets:
Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986876/
https://ncbi.nlm.nih.gov/pubmed/31934853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50979
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