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Filamin A-Bound PEBP2β/CBFβ Is Retained in the Cytoplasm and Prevented from Functioning as a Partner of the Runx1 Transcription Factor

The heterodimeric transcription factor PEBP2/CBF is composed of a DNA-binding subunit, called Runx1, and a non-DNA-binding subunit, called PEBP2β/CBFβ. The Runx1 protein is detected exclusively in the nuclei of most cells and tissues, whereas PEBP2β is located in the cytoplasm. We addressed the mech...

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Publicado no:Mol Cell Biol
Principais autores: Yoshida, Naomi, Ogata, Takehiro, Tanabe, Kenji, Li, Songhua, Nakazato, Megumi, Kohu, Kazuyoshi, Takafuta, Toshiro, Shapiro, Sandor, Ohta, Yasutaka, Satake, Masanobu, Watanabe, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC543995/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15657428/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.25.3.1003-1012.2005
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