Down-regulation of Runx1 Expression by TCR Signal Involves an Autoregulatory Mechanism and Contributes to IL-2 Production

Runx1 transcription factor plays multiple roles in T cell development, differentiation, and function. However, the regulatory mechanisms and functional significance of high Runx1 protein expression in resting peripheral CD4+ T cells is not well understood. Here, we demonstrate that T-cell receptor (...

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Bibliographische Detailangaben
Hauptverfasser: Wong, Won Fen, Kurokawa, Mineo, Satake, Masanobu, Kohu, Kazuyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064165/
https://ncbi.nlm.nih.gov/pubmed/21292764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166694
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