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Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

Although the large majority of solid tumors show a combination of mitotic spindle defects and chromosomal instability, little is known about the mechanisms that govern the initial steps in tumorigenesis. The recent report of spindle-induced DNA damage provides evidence for a single mechanism respons...

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Main Authors: Guerrero, Astrid Alonso, Martínez-A, Carlos, van Wely, Karel HM
格式: Artigo
語言:Inglês
出版: BioMed Central 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878296/
https://ncbi.nlm.nih.gov/pubmed/20478024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-5-13
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