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Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor

The lymphotoxin-β receptor (LTβR) activates the NF-κB2 transcription factors, p100 and RelB, by regulating the NF-κB-inducing kinase (NIK). Constitutive proteosomal degradation of NIK limits NF-κB activation in unstimulated cells by the ubiquitin:NIK E3 ligase comprised of subunits TNFR-associated f...

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Detalhes bibliográficos
Main Authors: Sanjo, Hideki, Zajonc, Dirk M., Braden, Rebecca, Norris, Paula S., Ware, Carl F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878066/
https://ncbi.nlm.nih.gov/pubmed/20348096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105874
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