SPHINGOSINE-1-PHOSPHATE: A MISSING COFACTOR FOR THE E3 UBIQUITIN LIGASE TRAF2

TNF receptor-associated factor 2 (TRAF2) is a key component in NF-κB signaling triggered by TNF–α 1,2. Genetic evidence indicates that TRAF2 is necessary for polyubiquitination of receptor interacting protein 1 (RIP1) 3 that then serves as a platform for recruitment and stimulation of IκB kinase (IK...

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Detalhes bibliográficos
Main Authors: Alvarez, Sergio E., Harikumar, Kuzhuvelil B., Hait, Nitai C., Allegood, Jeremy, Strub, Graham M., Kim, Eugene, Maceyka, Michael, Jiang, Hualiang, Luo, Cheng, Kordula, Tomasz, Milstien, Sheldon, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946785/
https://ncbi.nlm.nih.gov/pubmed/20577214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09128
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