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SPHINGOSINE-1-PHOSPHATE SIGNALING AND ITS ROLE IN DISEASE

The bioactive sphingolipid metabolite, sphingosine-1-phosphate (S1P), is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 a...

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Detalhes bibliográficos
Main Authors: Maceyka, Michael, Harikumar, Kuzhuvelil B., Milstien, Sheldon, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253987/
https://ncbi.nlm.nih.gov/pubmed/22001186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2011.09.003
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