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Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P...

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Main Authors: Kunkel, Gregory T., Maceyka, Michael, Milstien, Sheldon, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908769/
https://ncbi.nlm.nih.gov/pubmed/23954895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4099
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