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Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation

Caspase-8 is a cysteine protease activated by membrane-bound receptors at the cytosolic face of the cell membrane, initiating the extrinsic pathway of apoptosis. Caspase-8 activation relies on recruitment of inactive monomeric zymogens to activated receptor complexes, where they produce a fully acti...

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Main Authors: Oberst, Andrew, Pop, Cristina, Tremblay, Alexandre G., Blais, Véronique, Denault, Jean-Bernard, Salvesen, Guy S., Green, Douglas R.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878047/
https://ncbi.nlm.nih.gov/pubmed/20308068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.095083
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