Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

The modeling and remodeling of bone requires activation and polarization of osteoclasts, achieved by reorganization of the cytoskeleton. Members of the Rho subfamily of small GTPases, including Cdc42, are known regulators of cytoskeletal components, but the role of these proteins in bone physiology...

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Bibliografiska uppgifter
Huvudupphovsmän: Ito, Yuji, Teitelbaum, Steven L., Zou, Wei, Zheng, Yi, Johnson, James F., Chappel, Jean, Ross, F. Patrick, Zhao, Haibo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877929/
https://ncbi.nlm.nih.gov/pubmed/20501942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39650
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