Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

The modeling and remodeling of bone requires activation and polarization of osteoclasts, achieved by reorganization of the cytoskeleton. Members of the Rho subfamily of small GTPases, including Cdc42, are known regulators of cytoskeletal components, but the role of these proteins in bone physiology...

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Main Authors: Ito, Yuji, Teitelbaum, Steven L., Zou, Wei, Zheng, Yi, Johnson, James F., Chappel, Jean, Ross, F. Patrick, Zhao, Haibo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877929/
https://ncbi.nlm.nih.gov/pubmed/20501942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39650
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