Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

Unusually for a eukaryote, the malaria parasite Plasmodium falciparum expresses dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single bifunctional protein. The two activities contribute to the essential pathway of folate biosynthesis and modification. The DHFS activity of...

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Autori principali: Wang, Ping, Wang, Qi, Yang, Yonghong, Coward, James K., Nzila, Alexis, Sims, Paul F.G., Hyde, John E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier/North-Holland Biomedical Press 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877875/
https://ncbi.nlm.nih.gov/pubmed/20350571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2010.03.012
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