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Expression of Myocilin Mutants Sensitizes Cells to Oxidative Stress-Induced Apoptosis : Implication for Glaucoma Pathogenesis
Mutations in the myocilin gene are associated with juvenile and adult-onset primary open-angle glaucoma. However, the pathogenic mechanisms of myocilin-induced glaucoma are still largely unknown. To investigate these mechanisms, we developed stably transfected HEK293 cell lines expressing wild-type...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877849/ https://ncbi.nlm.nih.gov/pubmed/20382707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090853 |
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