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Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma
Glaucoma is a multifactorial optic neuropathy characterized by retinal ganglion cell (RGC) death and axonal degeneration leading to irreversible blindness. Mutations in the MYOCILIN (MYOC) gene are the most common genetic factors of primary open-angle glaucoma. To develop a genetic mouse model induc...
Gespeichert in:
| Veröffentlicht in: | Hum Mol Genet |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4447889/ https://ncbi.nlm.nih.gov/pubmed/25740847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv082 |
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