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Aggregated Myocilin Induces Russell Bodies and Causes Apoptosis : Implications for the Pathogenesis of Myocilin-Caused Primary Open-Angle Glaucoma
Primary open-angle glaucoma with elevated intraocular pressure is a leading cause of blindness worldwide. Mutations of myocilin are known to play a critical role in the manifestation of the disease. Misfolded mutant myocilin forms secretion-incompetent intracellular aggregates. The block of myocilin...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Investigative Pathology
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1762699/ https://ncbi.nlm.nih.gov/pubmed/17200186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060806 |
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