Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic organisms and also promotes protein-protein interactions. This enzymatic reaction is carried out by protein farnesyltransferase (PFT), which catalyzes the transfer of a 15-...

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Detalhes bibliográficos
Main Authors: Eastman, Richard T., White, John, Hucke, Oliver, Yokoyama, Kohei, Verlinde, Christophe L. M. J., Hast, Michael A., Beese, Lorena S., Gelb, Michael H., Rathod, Pradipsinh K., Van Voorhis, Wesley C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875941/
https://ncbi.nlm.nih.gov/pubmed/17208314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2006.11.012
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