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Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase
The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic organisms and also promotes protein-protein interactions. This enzymatic reaction is carried out by protein farnesyltransferase (PFT), which catalyzes the transfer of a 15-...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875941/ https://ncbi.nlm.nih.gov/pubmed/17208314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2006.11.012 |
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