GENETIC CHANGES DURING LABORATORY PROPAGATION: COPY NUMBER AT THE RETICULOCYTE BINDING PROTEIN 1 LOCUS OF PLASMODIUM FALCIPARUM

Comparative genomic hybridization studies have revealed elevated copy number (CN) at the reticulocyte binding protein 1 gene (PfRh1) in fast growing lab-adapted parasites, while genetic manipulation demonstrates a causal link between cell invasion and PfRh1 CN. We therefore examined PfRh1 copy numbe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nair, Shalini, Nkhoma, Standwell, Nosten, François, Mayxay, Mayfong, French, Neil, Whitworth, Jim, Anderson, Tim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875377/
https://ncbi.nlm.nih.gov/pubmed/20363264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2010.03.015
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