Adaptive Copy Number Evolution in Malaria Parasites

Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP. We provide compelling evide...

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Detalhes bibliográficos
Main Authors: Nair, Shalini, Miller, Becky, Barends, Marion, Jaidee, Anchalee, Patel, Jigar, Mayxay, Mayfong, Newton, Paul, Nosten, François, Ferdig, Michael T., Anderson, Tim J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570623/
https://ncbi.nlm.nih.gov/pubmed/18974876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000243
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