Adaptive Copy Number Evolution in Malaria Parasites

Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP. We provide compelling evide...

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Détails bibliographiques
Auteurs principaux: Nair, Shalini, Miller, Becky, Barends, Marion, Jaidee, Anchalee, Patel, Jigar, Mayxay, Mayfong, Newton, Paul, Nosten, François, Ferdig, Michael T., Anderson, Tim J. C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570623/
https://ncbi.nlm.nih.gov/pubmed/18974876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000243
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