Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes

Rad52 promotes the annealing of complementary strands of DNA bound by replication protein A (RPA) during discrete repair pathways. Here, we used a fluorescence resonance energy transfer (FRET) between two fluorescent dyes incorporated into DNA substrates to probe the mechanism by which human Rad52 (...

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Autores principales: Grimme, Jill M., Honda, Masayoshi, Wright, Rebecca, Okuno, Yusuke, Rothenberg, Eli, Mazin, Alexander V., Ha, Taekjip, Spies, Maria
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875008/
https://ncbi.nlm.nih.gov/pubmed/20081207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1249
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