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Inhibition of the Fe(4)S(4) Cluster-containing Protein IspH (LytB): EPR, Metallacycles and Mechanisms
We report the inhibition of the Aquifex aeolicus IspH enzyme (LytB, (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, EC 1.17.1.2) by a series of diphosphates and bisphosphonates. The most active species was an alkynyl diphosphate having an IC(50) = 0.45 μM (K(i) ~ 60 nM), which generated a v...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874468/ https://ncbi.nlm.nih.gov/pubmed/20426416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja909664j |
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