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Bioorganometallic Chemistry with IspG and IspH: Structure, Function and Inhibition of the [Fe(4)S(4)] Proteins Involved in Isoprenoid Biosynthesis
The methylerythritol phosphate pathway of isoprenoid biosynthesis is an attractive anti-infective drug target. The last two enzymes of this pathway, IspG and IspH, are [Fe(4)S(4)] proteins not produced by humans that catalyze 2H(+)/2e(−) reductions with novel mechanisms. In this review, we summarize...
में बचाया:
| मुख्य लेखकों: | , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3997630/ https://ncbi.nlm.nih.gov/pubmed/24481599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201306712 |
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