Inhibition of IspH, a [4Fe-4S](2+) enzyme involved in the biosynthesis of isoprenoids via the MEP pathway

The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target for the development of antimicrobial drugs. IspH, an oxygen-sensitive [4Fe-4S] enzyme, catalyzes the last step of this pathway and converts...

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Bibliographic Details
Main Authors: Janthawornpong, Karnjapan, Krasutsky, Sergiy, Chaignon, Philippe, Rohmer, Michel, Poulter, C. Dale, Seemann, Myriam
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644560/
https://ncbi.nlm.nih.gov/pubmed/23316732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309557s
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