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Inhibition of IspH, a [4Fe-4S](2+) enzyme involved in the biosynthesis of isoprenoids via the MEP pathway
The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target for the development of antimicrobial drugs. IspH, an oxygen-sensitive [4Fe-4S] enzyme, catalyzes the last step of this pathway and converts...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3644560/ https://ncbi.nlm.nih.gov/pubmed/23316732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309557s |
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