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Pyridine Inhibitor Binding to the 4Fe-4S Protein A. aeolicus IspH (LytB): A HYSCORE Investigation
IspH is a 4Fe-4S protein that carries out an essential reduction step in isoprenoid biosynthesis. Using hyperfine sublevel correlation (HYSCORE) spectroscopy, we show that pyridine inhibitors of IspH directly bind to the unique 4(th) Fe in the 4Fe-4S cluster, opening up new routes to inhibitor desig...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092291/ https://ncbi.nlm.nih.gov/pubmed/21486034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2008455 |
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