Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin.
A recombinant chimeric toxin in which the cell binding domain of Pseudomonas exotoxin (PE) was replaced by murine interleukin 4 (IL-4) was produced in Escherichia coli. This chimeric protein, IL-4-PE40, was cytotoxic to murine IL-4 receptor-bearing cell lines but had little effect on human cell line...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1989
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657746/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.11.4215 |
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