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Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin.

A recombinant chimeric toxin in which the cell binding domain of Pseudomonas exotoxin (PE) was replaced by murine interleukin 4 (IL-4) was produced in Escherichia coli. This chimeric protein, IL-4-PE40, was cytotoxic to murine IL-4 receptor-bearing cell lines but had little effect on human cell line...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ogata, M, Chaudhary, V K, FitzGerald, D J, Pastan, I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287421/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657746/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.11.4215
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