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Dual-targeting siRNAs

We have developed an algorithm for the prediction of dual-targeting short interfering RNAs (siRNAs) in which both strands are deliberately designed to separately target different mRNA transcripts with complete complementarity. An advantage of this approach versus the use of two separate duplexes is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tiemann, Katrin, Höhn, Britta, Ehsani, Ali, Forman, Stephen J., Rossi, John J., Sætrom, Pål
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874179/
https://ncbi.nlm.nih.gov/pubmed/20410240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2005710
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