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Dual-targeting siRNAs

We have developed an algorithm for the prediction of dual-targeting short interfering RNAs (siRNAs) in which both strands are deliberately designed to separately target different mRNA transcripts with complete complementarity. An advantage of this approach versus the use of two separate duplexes is...

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Autors principals: Tiemann, Katrin, Höhn, Britta, Ehsani, Ali, Forman, Stephen J., Rossi, John J., Sætrom, Pål
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874179/
https://ncbi.nlm.nih.gov/pubmed/20410240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2005710
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