Rational Design of Micro-RNA-like Bifunctional siRNAs Targeting HIV and the HIV Coreceptor CCR5

Small-interfering RNAs (siRNAs) and micro-RNAs (miRNAs) are distinguished by their modes of action. SiRNAs serve as guides for sequence-specific cleavage of complementary mRNAs and the targets can be in coding or noncoding regions of the target transcripts. MiRNAs inhibit translation via partially c...

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Hlavní autoři: Ehsani, Ali, Saetrom, Pål, Zhang, Jane, Alluin, Jessica, Li, Haitang, Snøve Jr, Ola, Aagaard, Lars, Rossi, John J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862539/
https://ncbi.nlm.nih.gov/pubmed/20104214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.321
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