Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients but does not eliminate leukemia stem cells (LSC), which remain a potential source of relapse. Here we investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined wi...

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Bibliografiset tiedot
Päätekijät: Zhang, Bin, Strauss, Adam C., Chu, Su, Li, Min, Ho, Yinwei, Shiang, Keh-Dong, Snyder, David S, Huettner, Claudia S., Shultz, Leonard, Holyoake, Tessa, Bhatia, Ravi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873971/
https://ncbi.nlm.nih.gov/pubmed/20478526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.03.011
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