Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients but does not eliminate leukemia stem cells (LSC), which remain a potential source of relapse. Here we investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined wi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhang, Bin, Strauss, Adam C., Chu, Su, Li, Min, Ho, Yinwei, Shiang, Keh-Dong, Snyder, David S, Huettner, Claudia S., Shultz, Leonard, Holyoake, Tessa, Bhatia, Ravi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873971/
https://ncbi.nlm.nih.gov/pubmed/20478526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.03.011
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge