A Synthetic 18-Norsteroid Distinguishes between Two Neuroactive Steroid Binding Sites on GABA(A) Receptors

In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [(35)S]t-butylbicyclophosphorothionate in a biphasic manner, with enhancement of binding at low concentrations (site NS1) and inhibition at higher concentrations (site NS2). In the current study, com...

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Detalhes bibliográficos
Main Authors: Evers, Alex S., Chen, Zi-Wei, Manion, Brad D., Han, Mingcheng, Jiang, Xin, Darbandi-Tonkabon, Ramin, Kable, Tristan, Bracamontes, John, Zorumski, Charles F., Mennerick, Steven, Steinbach, Joe Henry, Covey, Douglas F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872955/
https://ncbi.nlm.nih.gov/pubmed/20124410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.164079
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