Neurosteroid Analogues. 17. Inverted Binding Orientations of Androsterone Enantiomers at the Steroid Potentiation Site on γ-Aminobutyric Acid Type A (GABA(A)) Receptors

The enantiomer pair androsterone and ent-androsterone are positive allosteric modulators of γ-aminobutyric acid type A (GABA(A)) receptors. Each enantiomer was shown to bind at the same receptor site. Binding orientations of the enantiomers at this site were deduced using enantiomer pairs containing...

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Main Authors: Krishnan, Kathiresan, Manion, Brad D., Taylor, Amanda, Bracamontes, John, Steinbach, Joseph H., Reichert, David E., Evers, Alex S., Zorumski, Charles F., Mennerick, Steven, Covey, Douglas F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276733/
https://ncbi.nlm.nih.gov/pubmed/22191644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2014925
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