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Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

The VP35 protein encoded by the highly pathogenic Ebola virus facilitates immune evasion by antagonizing antiviral signaling pathways, including those initiated by RIG-I like receptors. Here we report the crystal structure of Ebola VP35 interferon inhibitory domain (IID) bound to short double-strand...

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Библиографические подробности
Главные авторы: Leung, Daisy W., Prins, Kathleen C., Borek, Dominika M., Farahbakhsh, Mina, Tufariello, JoAnn M., Ramanan, Parameshwaran, Nix, Jay C., Helgeson, Luke, Otwinowski, Zbyszek, Honzatko, Richard B., Basler, Christopher F., Amarasinghe, Gaya K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872155/
https://ncbi.nlm.nih.gov/pubmed/20081868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1765
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