Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

The VP35 protein encoded by the highly pathogenic Ebola virus facilitates immune evasion by antagonizing antiviral signaling pathways, including those initiated by RIG-I like receptors. Here we report the crystal structure of Ebola VP35 interferon inhibitory domain (IID) bound to short double-strand...

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Autori principali: Leung, Daisy W., Prins, Kathleen C., Borek, Dominika M., Farahbakhsh, Mina, Tufariello, JoAnn M., Ramanan, Parameshwaran, Nix, Jay C., Helgeson, Luke, Otwinowski, Zbyszek, Honzatko, Richard B., Basler, Christopher F., Amarasinghe, Gaya K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872155/
https://ncbi.nlm.nih.gov/pubmed/20081868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1765
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