Phosphatidic Acid Is a Leukocyte Chemoattractant That Acts through S6 Kinase Signaling

Phosphatidic acid (PA) is a pleiotropic lipid second messenger in mammalian cells. We report here that extracellular PA acts as a leukocyte chemoattractant, as membrane-soluble dioleoyl-PA (DOPA) elicits actin polymerization and chemotaxis of human neutrophils and differentiated proleukemic HL-60 ce...

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Bibliographic Details
Main Authors: Frondorf, Kathleen, Henkels, Karen M., Frohman, Michael A., Gomez-Cambronero, Julian
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871451/
https://ncbi.nlm.nih.gov/pubmed/20304930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070524
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