Expression of the Anti-amyloidogenic Secretase ADAM10 Is Suppressed by Its 5′-Untranslated Region

Proteolytic processing of the amyloid precursor protein by α-secretase prevents formation of the amyloid β-peptide (Aβ), which is the main constituent of amyloid plaques in brains of Alzheimer disease (AD) patients. α-Secretase activity is decreased in AD, and overexpression of the α-secretase ADAM1...

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Autors principals: Lammich, Sven, Buell, Dominik, Zilow, Sonja, Ludwig, Ann-Katrin, Nuscher, Brigitte, Lichtenthaler, Stefan F., Prinzen, Claudia, Fahrenholz, Falk, Haass, Christian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871442/
https://ncbi.nlm.nih.gov/pubmed/20348102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.110742
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