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Expression of the Anti-amyloidogenic Secretase ADAM10 Is Suppressed by Its 5′-Untranslated Region
Proteolytic processing of the amyloid precursor protein by α-secretase prevents formation of the amyloid β-peptide (Aβ), which is the main constituent of amyloid plaques in brains of Alzheimer disease (AD) patients. α-Secretase activity is decreased in AD, and overexpression of the α-secretase ADAM1...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871442/ https://ncbi.nlm.nih.gov/pubmed/20348102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.110742 |
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