Exploration and Optimization of Substituted Triazolothiadiazines and Triazolopyridazines as PDE4 Inhibitors

An expansion of structure-activity studies on a series of substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine PDE4 inhibitors and the introduction of a related [1,2,4]triazolo[4,3-b]pyridazine based inhibitor of PDE4 is presented. The development of SAR included strategic incorporation of known...

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Bibliografski detalji
Glavni autori: Skoumbourdis, Amanda P., LeClair, Christopher A., Stefan, Eduard, Turjanski, Adrian G., Maguire, William, Titus, Steven A., Huang, Ruili, Auld, Douglas S., Inglese, James, Austin, Christopher P., Michnick, Stephen W., Xia, Menghang, Thomas, Craig J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870997/
https://ncbi.nlm.nih.gov/pubmed/19464886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.01.057
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